RecruitingNCT04025515

Molecular Profiling Project

ATORG001 - Molecular Profiling Project


Sponsor

National Cancer Centre, Singapore

Enrollment

500 participants

Start Date

Jan 11, 2019

Study Type

OBSERVATIONAL

Conditions

Summary

In this study, the investigators plan to undertake comprehensive molecular profiling of "actionable" alterations in lung cancer specimens in order to determine the prevalence of each genetic subtype in the local population.


Eligibility

Min Age: 21 Years

Inclusion Criteria9

  • The availability of sufficient archival tumor tissue specimen (15 slides of 4 microns per section)
  • Age ≥ 21 years
  • WHO performance status ≤ 2
  • Life expectancy of ≥ 12 weeks
  • Patients should have adequate organ function for potential consideration into clinical trials (routine blood tests are valid within 14 days before enrollment):
  • Adequate bone marrow function as shown by: ANC ≥ 1.0 x 10\^9/L, Platelets ≥ 75 x 10\^9/L, Hb ≥ 7.5 g/dL
  • Alanine aminotransferase (ALT) and aspirate aminotransferase (AST) normal range (or ≤3.0 x ULN if liver metastases are present)
  • Willing to provide signed informed consent
  • Patients whom do not fulfill the above criteria may be discussed on a case-by-case basis with the study team, for potential enrolment

Exclusion Criteria1

  • \- No more than 3 lines of cytotoxic chemotherapy at the time of enrolment

Locations(10)

The Brunei Cancer Centre

Brunei, Brunei

Hong Kong Integrated Oncology Centre

Hong Kong, Hong Kong

The Chinese University of Hong Kong, Department of Clinical Oncology

Hong Kong, Hong Kong

Rajiv Ghandhi Cancer Institute and Research Centre

New Delhi, India

Penang Adventist Hospital

George Town, Malaysia

Pantai Hospital, Kuala Lumpur

Kuala Lumpur, Malaysia

University Malaya Medical Centre, Clinical Oncology Department

Kuala Lumpur, Malaysia

Beacon Hospital

Petaling Jaya, Malaysia

National Cancer Centre Singapore

Singapore, Singapore

Phramongkutklao Hospital

Bangkok, Thailand

View Full Details on ClinicalTrials.gov

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NCT04025515


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