RecruitingEarly Phase 1NCT04026776

Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

Sponsor

Wake Forest University Health Sciences

Enrollment

120 participants

Start Date

Sep 2, 2020

Study Type

INTERVENTIONAL

Conditions

Blood Pressure Disorders Salt; Excess

Summary

The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.

Eligibility

Min Age: 22 YearsMax Age: 33 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Allopurinol and Dietary Intervention for people with blood pressure disorders and salt; excess. The study is currently recruiting participants at 1 location. People eligible for this study include aged 22 Years to 33 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAllopurinol

Study Part 2- Preterm group only: After Visit 5 preterm born participants will start allopurinol 200 mg daily PO for 6 weeks. The 1 week high and low salt diets and assessments will be repeated while on allopurinol.

OTHERDietary Intervention

High-Na+ (250 mmol/d) and low-Na+ (50 mmol/d) standard isocaloric K+ diets (75 mmol/1000 kcal/d) for 1 week each as 3 meals and 1 snack a day provided by the Clinical Research Unit Metabolic Kitchen. Part 2 preterm only- the diets will be repeated while the participant is taking allopurinol.