Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
Wake Forest University Health Sciences
120 participants
Sep 2, 2020
INTERVENTIONAL
Conditions
Summary
The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.
Eligibility
Inclusion Criteria3
- Singleton birth
- Born at less than 34 weeks gestational age (preterm cohort)
- Born at greater than 36 weeks gestational age (term cohort)
Exclusion Criteria9
- Twin birth
- Congenital anomalies or genetic syndromes
- Currently pregnant or breast feeding
- Subject-reported history of hypertension
- Current use of antihypertensive medications
- Active cancer
- Chronic kidney disease
- Heart failure
- Liver failure
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Study Part 2- Preterm group only: After Visit 5 preterm born participants will start allopurinol 200 mg daily PO for 6 weeks. The 1 week high and low salt diets and assessments will be repeated while on allopurinol.
High-Na+ (250 mmol/d) and low-Na+ (50 mmol/d) standard isocaloric K+ diets (75 mmol/1000 kcal/d) for 1 week each as 3 meals and 1 snack a day provided by the Clinical Research Unit Metabolic Kitchen. Part 2 preterm only- the diets will be repeated while the participant is taking allopurinol.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04026776