RecruitingNCT04046796
Genetic Causes of Discrepant Clinic in Monogenic Twins
Sponsor
University Hospital Tuebingen
Enrollment
50 participants
Start Date
Dec 1, 2019
Study Type
OBSERVATIONAL
Conditions
Summary
In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or re-analysed using existing datasets. Phenotype and omics data will be shared within the University Hospital Tübingen and with external collaborators to improve the diagnostic rate of the subjects included in the study.
Eligibility
Inclusion Criteria3
- Twin pair monozygotic clinically (phenotypic) discordant twins
- Unclear diagnosis
- Suspected (mono-)genetic cause of the disease in one twin
Exclusion Criteria2
- Missing informed consent of both twin/ legal representative
- No distinct phenotype
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
GENETICNGS Diagnostic
Blood take for genetic diagnostic.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04046796
Related Trials
Genetic Analysis of Uncommon Disease Presentations in Non-US Populations
NCT065959401 location
Longitudinal Studies of Patient With FPDMM
NCT038543181 location
Enhancing Information Management for Young Adults After Genetic Cancer Risk Testing
NCT057591431 location
Germline Testing for Predisposition to Myeloid Malignancies
NCT071122871 location
Epidemiological Study of Treatment Approaches in AChR-Antibody Positive Generalized Myasthenia Gravis in Russia
NCT072472795 locations