RecruitingNCT04058457

DBS and Respiration

Deep Brain Stimulation in Parkinson's Disease: Respiratory Testing

Sponsor

University of Oxford

Enrollment

60 participants

Start Date

Apr 1, 2021

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease

Summary

Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of neurological conditions, most commonly Parkinson's disease. The investigators have observed that respiratory problems (breathlessness) sometimes occur subsequent to DBS of the subthalamic nucleus (STN). This study aims to determine whether this is indeed a consequence of STN stimulation. Secondary objectives include identification of the respiratory physiological mediators of any interoceptive neuromodulation observed, changes in daily physical activity and MRI structural connectivity analysis.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how deep brain stimulation (DBS) — a surgical treatment that delivers electrical signals to specific parts of the brain — affects breathing. Researchers want to better understand the connection between brain stimulation and the respiratory system, particularly in people with Parkinson's disease. **You may be eligible if...** - You are 18 years or older - You are already scheduled to receive DBS surgery - You are fluent in English - If joining the Parkinson's group: you have a Parkinson's disease diagnosis **You may NOT be eligible if...** - You are pregnant - You are currently in another clinical trial that involves an active treatment affecting your breathing - You have an active respiratory condition at the time of testing (such as a sinus infection, sore throat, or asthma flare-up) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEDBS

Patients are tested pre-operatively and the post-operatively with their implanted neurostimulators ON and OFF. DBS implantation itself is part of routine care, and not part of the study.