Correlation Between TILs and Blood Cell Counts in Triple Negative Breast Cancer Patients
PERCEPTION Trial Protocol: Comparison of Predictive and Prognostic Capacities of Neutrophil, Lymphocyte and Platelet Counts and Tumour-infiltrating Lymphocytes in Triple Negative Breast Cancer
Centre Jean Perrin
90 participants
Dec 4, 2019
OBSERVATIONAL
Summary
The PERCEPTION study aims to assess the correlation between blood cell counts (Leucocytes, Neutrophils, Lymphocytes, Platelets, NLR (Neutrophil-to-Lymphocyte Ratio) and PLR (Platelet-to-Lymphocyte Ratio)) and Tumor Infiltrating Lymphocytes (TILs), at baseline and after surgery, for patients diagnosed with triple negative breast cancer. It also aims to assess these circulating elements and circulating tumor DNA as predictive factor of metastatic recurrence in triple negative breast cancer.
Eligibility
Inclusion Criteria7
- Female
- Age \> 18 years
- Diagnosed with primitive, non-metastatic, histologically proved, triple negative breast cancer
- Patient treated with chemotherapy, surgery and radiation therapy
- Patient able to understand the French language
- Patient affiliated to social security
- Obtaining signed written consent
Exclusion Criteria3
- Male
- Unavailable tumoral samples before inclusion
- Unavailable blood test results at baseline, before inclusion
Interventions
Blood samples will be collected at 12 months after radiation therapy and at the time of first metastatic recurrence
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04068623