RecruitingNCT04068623

Correlation Between TILs and Blood Cell Counts in Triple Negative Breast Cancer Patients

PERCEPTION Trial Protocol: Comparison of Predictive and Prognostic Capacities of Neutrophil, Lymphocyte and Platelet Counts and Tumour-infiltrating Lymphocytes in Triple Negative Breast Cancer


Sponsor

Centre Jean Perrin

Enrollment

90 participants

Start Date

Dec 4, 2019

Study Type

OBSERVATIONAL

Summary

The PERCEPTION study aims to assess the correlation between blood cell counts (Leucocytes, Neutrophils, Lymphocytes, Platelets, NLR (Neutrophil-to-Lymphocyte Ratio) and PLR (Platelet-to-Lymphocyte Ratio)) and Tumor Infiltrating Lymphocytes (TILs), at baseline and after surgery, for patients diagnosed with triple negative breast cancer. It also aims to assess these circulating elements and circulating tumor DNA as predictive factor of metastatic recurrence in triple negative breast cancer.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether the number and type of immune cells in breast cancer tissue (called tumor-infiltrating lymphocytes, or TILs) are related to changes in routine blood test results in women with triple-negative breast cancer — an aggressive form of the disease that lacks three common hormone receptors. **You may be eligible if...** - You are female and over 18 years old - You have been diagnosed with triple-negative breast cancer that has not spread to distant organs - You have received chemotherapy, surgery, and radiation therapy - You can understand French - You are enrolled in French social security **You may NOT be eligible if...** - You are male - Tumor tissue samples from before treatment are not available - Blood test results from the beginning of your treatment are not available Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBlood sample

Blood samples will be collected at 12 months after radiation therapy and at the time of first metastatic recurrence


Locations(1)

Centre Jean PERRIN

Clermont-Ferrand, Please Select, France

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NCT04068623