Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
Jessa Hospital
40 participants
Sep 1, 2019
OBSERVATIONAL
Conditions
Summary
In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well. The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.
Eligibility
Inclusion Criteria4
- must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain \<0.6, measured by the video-HIT5 or scleral-coil technique and/or
- reduced caloric response6 (sum of bither- mal max. peak SPV on each side \<6◦/sec7) and/or
- reduced horizontal angular VOR gain \<0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50◦ /sec) and a phase lead \>68 degrees (time constant \<5 sec).
- must be 18 or older
Exclusion Criteria3
- \< 18 y
- does not meet Barany criteria for BV
- contraindication for CT and MR imaging
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Interventions
videonystagmography
video head impulse test
vestibular evoked myogenic potentials to measure the function of otolith organs
tonal liminar audiometric thresholds
Ct and MR imaging of temporal bone
analysis of presence of p.P51S mutation in COCH
Locations(1)
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NCT04070937