AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

This study tests a type of bone marrow transplant (allogeneic stem cell transplant) using a specially processed donor cell product that has certain immune cells removed — reducing the risk of a dangerous complication called graft-versus-host disease (when the donor's immune cells attack the patient's body). It is offered to children and young adults with blood cancers or serious blood disorders. **You may be eligible if...** - You are between 0 and 30 years old - You have a high-risk blood cancer (such as ALL or AML) in remission or relapse, or a blood disorder like sickle cell disease, Diamond-Blackfan anemia, or MDS - Your organ function is adequate - A suitable donor is available **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have an uncontrolled infection - Your health and performance is too low (Karnofsky/Lansky score below 60) - You have had another bone marrow transplant in the past 6 months (unless it's a boost procedure) - You have active graft-versus-host disease Talk to your doctor to see if this trial is right for you.