RecruitingNCT04114084

Sleep Apnea in Patients With MGUS and MM

Sponsor

Michael Tomasson

Enrollment

200 participants

Start Date

May 23, 2019

Study Type

OBSERVATIONAL

Conditions

Multiple Myeloma Monoclonal Gammopathy of Undetermined Significance

Summary

This study involves patients with plasma cell dyscrasia including monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma (MM), with and without sleep apnea, who are providing bone marrow specimens. Specimens will be obtained at the time that patients undergo a standard-of-care procedure in order to minimize discomfort and reduce any risk.

Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether people with MGUS (a pre-cancer blood condition) or multiple myeloma (a blood cancer) are more likely to have sleep apnea — a condition where breathing repeatedly stops during sleep. Researchers want to know if these conditions are connected. **You may be eligible if...** - You have been diagnosed with MGUS (monoclonal gammopathy of undetermined significance) or multiple myeloma - You are already scheduled to have a bone marrow biopsy as part of your standard medical care **You may NOT be eligible if...** - You do not have a diagnosis of MGUS or multiple myeloma - You are not already having a bone marrow biopsy as part of your care Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREBone Marrow Aspirate and Biopsy

The aspirate sample obtained for research at the time a standard-of-care biopsy is taking place will be approximately 40cc. Bone marrow aspiration removes bone marrow fluid and cells through a needle placed into the bone. Usually this sample is taken from the back of the pelvic bone, but it may also be taken from the sternum or the front of the pelvic bone. A bone marrow biopsy removes bone with the marrow inside and is done prior to the aspirate. Each biopsy and aspirate procedure takes approximately 15 minutes total. Bone marrow aspirate may be collected in a separate tube for research or collected from the standard-of-care specimen with left-over aspirate not otherwise needed for clinical purposes, or from previous procedures.