RecruitingNot ApplicableNCT04114799

Haemodynamical Optimization During Brain Surgery

A Comparison of Perioperative Fluid Management Using Invasive Haemodynamical Measurement of Fluid Responsiveness (Aisys GE) and Non-invasive Measurement of Haemodynamics (ClearSight System, Edwards) During Brain Surgery

Sponsor

University Hospital Hradec Kralove

Enrollment

50 participants

Start Date

Apr 1, 2019

Study Type

INTERVENTIONAL

Conditions

Brain Edema

Summary

The decision to give fluids perioperatively could be based on methods used to identify preload responsiveness, either invasive or noninvasive estimates of stroke volume variation during mechanical ventilation. This study compares fluid management using invasive measurement SPV/PPV (Aisys GE) and noninvasive haemodynamic measurement (ClarSight, Edwards).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Hemodynamic management based on invasive fluid responsiveness parameters and a procedure called Hemodynamic management based on noninvasive cardiac output and SVV measurement for people with brain edema. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREHemodynamic management based on invasive fluid responsiveness parameters

In case of hypotension (reduction of MAP for more than 15% of individual blood pressure) the SPV value more than 8% will be used as a trigger for the bolus of 2 ml/kg of Plasmalyte (Baxter)

PROCEDUREHemodynamic management based on noninvasive cardiac output and SVV measurement

In case of hypotension (reduction of MAP for more than 15% of individual blood pressure) the systemic vascular resistance (SVR) value will be used to trigger norepinephrine infusion. In patients with low SVR norepinephrine infusion will be started. In patients with high SVR value either fluid bolus (in patient with SVV value above 8%), or dobutamine infusion (in patients with SVV value below or equal 8%) will be used.

Locations(1)

University Hospital Hradec Kralove

Hradec Králové, Czechia

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