RecruitingPhase 2NCT04115163

Biologically Optimized Infusion Schedule of Gemcitabine and Nab-Paclitaxel for the Treatment of Metastatic Pancreatic Cancer

A Pilot Study of Biologically Optimized Infusion Schedule of Gemcitabine and Nab-Paclitaxel in Metastatic Pancreatic Adenocarcinoma


Sponsor

Anne Noonan

Enrollment

67 participants

Start Date

Jun 24, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This phase II trial studies how well a biologically optimized infusion schedule of gemcitabine and nab-paclitaxel works in treating patients with pancreatic cancer that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as gemcitabine and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Altering the timing of the nab-paclitaxel infusion may improve response in patients with pancreatic cancer.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether giving the standard chemotherapy drugs gemcitabine and nab-paclitaxel on a different schedule — designed to match how the body processes them biologically — works better for people with metastatic pancreatic cancer. **You may be eligible if...** - You have been diagnosed with pancreatic cancer (adenocarcinoma) that has spread to other parts of the body (metastatic) - Your cancer is measurable on a CT or MRI scan - You are not pregnant or breastfeeding - If you are a woman who could become pregnant, you must agree to use effective contraception and have a negative pregnancy test before starting treatment **You may NOT be eligible if...** - You have a different type of pancreatic tumour (such as an islet cell tumour, not adenocarcinoma) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGGemcitabine

Given IV

DRUGNab-paclitaxel

Given IV


Locations(1)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

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NCT04115163


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