Antisecretory Factor In Severe Traumatic Brain Injury
Evaluation of Antisecretory Factor in Treatment of Severe Traumatic Brain Injury With Multimodal Monitoring
Peter Siesjö
20 participants
Mar 10, 2020
INTERVENTIONAL
Conditions
Summary
This study evaluates the addition of Salovum, an egg yolk powder enriched for antisecretory factor, to standard care of participants with severe traumatic brain injury. Half of the participants will be administered Salovum while the other half will be given a placebo egg yolk powder, not enriched for antisecretory factor. Intracranial pressure (ICP), partial brain oxygen pressure (PtbO2), microdialysis of metabolites and inflammatory mediators and trauma intensity level (TIL) will be assessed in all patients.
Eligibility
Inclusion Criteria3
- Severe traumatic brain injury, Glasgow Outcome Scale (GCS) <9 at admission to NICU.
- Clinical indication for insertion of intracranial pressure monitor, intracerebral oxygen pressure monitor and microdialysis catheter.
- Consultation with relatives or consent from guardians.
Exclusion Criteria2
- Known egg yolk allergy.
- Unilateral or bilateral fixed and dilated pupil after initial operative intervention.
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Interventions
Active egg yolk powder
Normal egg yolk powder
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04117672