RecruitingNot ApplicableNCT04119908

Videomicroscopy for the Prediction of Bleeding in Constitutional Haemorrhagic Diseases

Interest of Sublingual Videomicroscopy for the Prediction of Bleeding in Von Willebrand Disease and Other Constitutional Haemorrhagic Diseases


Sponsor

University Hospital, Lille

Enrollment

400 participants

Start Date

May 24, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

In Willebrand disease, there is currently no test available to identify non-invasively patients with a high risk of bleeding from angiodysplasias The study propose to use a sublingual capillary bed analysis by video-microscopy, a sensitive, reproducible and non-invasive technique, to assess whether sublingual capillary density is predictive of hemorrhagic risk for patients with von Willebrand disease.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using a cutting-edge microscopy technique to observe how blood vessels and platelets behave in patients with inherited bleeding disorders, including von Willebrand disease, Glanzmann Thrombasthenia, moderate to severe Hemophilia A, and women who carry the hemophilia gene. Understanding exactly how blood clotting is impaired at the microscopic level may help doctors better predict bleeding risk and guide treatment decisions for these patients. You may be eligible if: - You are an adult (18 years or older) - You have been diagnosed with a significant form of von Willebrand disease (according to the French Willebrand Disease Reference Center criteria), Glanzmann Thrombasthenia, moderate to severe Hemophilia A, or you are a woman who carries the hemophilia gene - You are enrolled in the French social security system You may NOT be eligible if: - You are under 18 years old - You refuse to give consent - You are under a legal protection order - You are pregnant Talk to your hematologist if you have a diagnosed inherited bleeding disorder — this study may offer deeper insight into how your condition affects clotting at the microscopic level, potentially improving the way your care is managed.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICESublingual videomicroscopy

Measurement of sublingual capillary density by video microscopy

BIOLOGICALblood sample

Collection of citrate tubes of 5 mL at baseline and at 36 months


Locations(1)

CHU de Lille

Lille, Nord, France

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NCT04119908


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