Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic Sarcoma

This study is testing whether focused ultrasound — a non-invasive technology that uses sound waves to heat and treat a tumour — can stimulate the immune system to attack undifferentiated pleomorphic sarcoma (UPS), a rare and aggressive soft tissue cancer. The hope is that treating one tumour site may help the immune system fight cancer elsewhere in the body. **You may be eligible if...** - You are 18 years old or older - You have been recently diagnosed with UPS (within the last 6 months) or have a suspected recurrence confirmed by scan - Your tumour is between 2 cm and 20 cm in size and is located in the chest, abdomen, pelvis, or limbs - Your tumour is clearly visible on MRI and is more than 1 cm from any vital structure (nerves, blood vessels, bowel, or skin) - You are in good physical condition (ECOG 0 or 1) - If newly diagnosed, your tumour is considered surgically removable **You may NOT be eligible if...** - Your tumour is less than 2 cm or greater than 20 cm - Your tumour is too close to critical structures or cannot be seen on MRI - You are not in good enough physical condition (ECOG 2 or above) Talk to your doctor to see if this trial is right for you.