HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia

This study is testing a DNA vaccine delivered using a small electric pulse (called electroporation) to treat high-grade cervical pre-cancer (CIN2/3) caused by the HPV16 virus. Two groups are included: people with and without HIV. **You may be eligible if...** - You are 19 or older - You have been diagnosed with a high-grade cervical lesion (CIN2/3) confirmed by colposcopy and biopsy - Your HPV test is positive for HPV16 - You are either HIV-negative or HIV-positive with a controlled viral load (under 200 copies/mL) and willing to stay on HIV medication - Your blood counts and organ function are within acceptable levels - You agree to use two forms of contraception during and for 3 months after the study **You may NOT be eligible if...** - Your lesion is HPV16-negative - You have HIV with an uncontrolled viral load (over 200 copies/mL) or active AIDS-related illness - You have a pacemaker, deep brain stimulator, or certain metal implants at the injection site - You have a history of seizures or epilepsy - You are pregnant or breastfeeding - You have a history of severe autoimmune disease (except mild thyroid conditions, psoriasis, or inflammatory bowel disease) Talk to your doctor to see if this trial is right for you.