Implantable Microdevice In Primary Brain Tumors

This study is testing a tiny implantable device placed directly into a brain tumor during surgery, which releases very small amounts of multiple drugs to test which ones are most effective at treating the tumor in each individual patient. **You may be eligible if...** - You are 18 or older - You have a brain tumor (glioma, grade II-IV) that is being surgically removed - Your overall health and performance level are adequate (Karnofsky Performance Score ≥ 60) - Your blood counts and organ function are within acceptable levels - You agree to use contraception during the study **You may NOT be eligible if...** - Your tumor is smaller than 5 cm³ or located in deep brain structures (like the thalamus or brainstem) - You have had chemotherapy or radiation within the past 4 weeks - You have an active infection, significant heart problems, or other serious uncontrolled illness - You have a bleeding disorder that cannot be corrected - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.