Concurrent Chemotherapy for Recurrent T3/T4 Nasopharyngeal Carcinoma

This study is testing whether adding chemotherapy at the same time as re-irradiation (radiation therapy given a second time) improves outcomes for people with locally recurrent nasopharyngeal carcinoma — a type of cancer at the back of the nose near the throat — that has come back after initial treatment. **You may be eligible if...** - You have confirmed locally recurrent nasopharyngeal carcinoma at stage T3 or T4 (advanced local tumor) - Your cancer has not spread to distant parts of the body - It has been more than 1 year since you finished your first course of radiation - You are between 18 and 70 years old with good performance status (ECOG 0-2) - Your blood counts and organ function are within acceptable limits **You may NOT be eligible if...** - Your cancer has spread to distant organs - You have evidence of only regional (lymph node) recurrence, not local - You have had other cancers (with some exceptions) - You are pregnant or breastfeeding - You have severe heart, brain, or lung problems - Your tissue in the back of the throat has areas of severe dead tissue (necrosis) Talk to your doctor to see if this trial is right for you.