RecruitingNCT04142047

Skeletal Muscle Energetics and Fatiguability in Older Individuals

Sponsor

Johns Hopkins University

Enrollment

200 participants

Start Date

Jan 3, 2019

Study Type

OBSERVATIONAL

Conditions

HIV Infections HIV

Summary

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Eligibility

Min Age: 60 YearsMax Age: 90 Years

Inclusion Criteria3

Participants who are \>= 60 years of age
HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies).
HIV serostatus negative participants

Exclusion Criteria6

Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
Contraindications to MRI
Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
Significant lower extremity peripheral vascular disease.
Weight greater than 350 lbs
Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.