Conservative Endometrioma Surgery
BLAST: a Randomized Controlled Trial on Conservative Endometrioma Surgery Using the CO2 Laser: the Combined Technique Versus CO2 Laser Vaporization Only
Universitaire Ziekenhuizen KU Leuven
92 participants
Oct 24, 2019
INTERVENTIONAL
Conditions
Summary
To study which surgical technique offers better results in treating endometriomas in terms of ovarian reserve preservation. The 2 conservatives techniques used are: 1. The combined technique 2. CO2 laser vaporization only Ovarian reserve will be assessed by consecutive measurements of AMH serum levels before and after surgery.
Eligibility
Inclusion Criteria7
- Population: patients planned for laparoscopic CO2 laser surgery for endometriotic cysts.
- Age: 18 - 40 years (both inclusive)
- Unilateral endometriotic cysts with a mean diameter of \>=2.5cm and ≤8 cm, measured in 3 dimensions.
- Presence of a contralateral endometrioma of ≤ 2cm is allowed
- Complaining of infertility and/or pain
- BMI ≤35
- Use of contraception (combined or Progesteron only) for at least 4 weeks before surgery
Exclusion Criteria10
- Incomplete surgery for the pelvis
- Contra-indication for the use of contraception (combined or Progesteron only)
- Use of GnRH analogues preoperatively and in the first 3 months postoperatively
- (History of) hysterectomy
- Prior unilateral oophorectomy
- Pituitary/hypothalamic disorders
- Suspected malignancy
- Contralateral endometrioma of \>2 cm
- AMH \<0.7 preoperatively
- Pregnancy
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Interventions
cf. different arms
Locations(4)
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NCT04151433