RecruitingPhase 1Phase 2NCT04156893

RH Genotype Matched RBC Transfusions

RH Genotype Matched Red Cell Transfusions for Patients With Sickle Cell Disease

Sponsor

Children's Hospital of Philadelphia

Enrollment

35 participants

Start Date

Jan 30, 2020

Study Type

INTERVENTIONAL

Conditions

Sickle Cells Disease

Summary

To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

Eligibility

Min Age: 6 Months

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called Red cell units that are genotype matched at the RHD and RHCE loci for people with sickle cells disease. The study is currently recruiting participants at 1 location. People eligible for this study include aged 6 Months and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALRed cell units that are genotype matched at the RHD and RHCE loci

Patients will be provided with red cell units that are C, E, and K antigen matched (standard of care for patients with SCD) and genotype matched at the RHD and RHCE loci.

Locations(1)

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

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NCT04156893