RecruitingPhase 1NCT04157127

Th-1 Dendritic Cell Immunotherapy Plus Standard Chemotherapy for Pancreatic Adenocarcinoma

Phase I Study of Th-1 Dendritic Cell Immunotherapy in Combination With Standard Chemotherapy for the Adjuvant Treatment of Pancreatic Adenocarcinoma (DECIST)


Sponsor

Diakonos Oncology Corporation

Enrollment

18 participants

Start Date

Aug 3, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This is a phase 1, first in human, dose escalation study for safety and feasibility of multi-dose dendritic cell (DC) therapy for pancreatic ductal adenocarcinoma (PDAC) including adenosquamous carcinoma administered after surgical resection of PDAC.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a personalized immune therapy for patients with pancreatic cancer who are going to have surgery. The treatment uses dendritic cells (a type of immune cell) that are engineered in the lab to stimulate the immune system to fight cancer. This vaccine is given alongside standard chemotherapy, before or after surgery, with the goal of improving long-term outcomes. **You may be eligible if...** - You are 18 or older with confirmed pancreatic adenocarcinoma that may be surgically removable (resectable or borderline resectable) - Your cancer may be treated with surgery upfront or after chemotherapy with or without radiation - Your blood counts, kidney, and liver function are within acceptable ranges - You have signed an informed consent form **You may NOT be eligible if...** - Your cancer has already spread to distant organs (metastatic) - Your organ function is significantly compromised Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BIOLOGICALAutologous DC Therapy

Autologous DC Therapy


Locations(3)

Baylor College of Medicine Medical Center - McNair Campus

Houston, Texas, United States

Baylor St. Lukes Medical Center

Houston, Texas, United States

Dan L. Duncan Cancer Center at Baylor College of Medicine

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04157127


Related Trials