Brain Imaging of Cognition Inn Schizophrenia and Depression

This study uses brain MRI scans to investigate how people with schizophrenia or major depression process information differently compared to healthy individuals. By measuring brain activity during cognitive tasks, researchers hope to better understand the brain mechanisms behind these mental health conditions and potentially discover new treatment targets. **You may be eligible if...** - You are between 18 and 65 years old - You have a diagnosis of schizophrenia, schizoaffective disorder, or major depressive disorder - Your IQ is above 70 (measured by a brief test) - You can read and speak fluent English - Your medication has been stable for more than one month **You may NOT be eligible if...** - You have a significant neurological condition that could affect cognition - You have had substance abuse or dependence in the past 3 months - You have any MRI contraindications (e.g., metal implants, pacemaker, history of seizures) - You take medications with a severe anticholinergic effect or daily benzodiazepines Talk to your doctor to see if this trial is right for you.