Treatment of Metastatic Vulvar Carcinoma With Carboplatin and Paclitaxel Chemotherapy

This study is testing carboplatin and paclitaxel chemotherapy — a combination commonly used in other cancers — for women with metastatic (widely spread) vulvar cancer. Metastatic vulvar cancer is rare and has few standard treatment options; this trial aims to establish whether this chemotherapy combination is effective and well tolerated. **You may be eligible if...** - You are a woman 18 or older - You have histologically confirmed squamous cell vulvar carcinoma that has spread to distant organs (stage M1) - Your cancer is measurable on imaging - You have adequate blood, liver, and kidney function - You have a negative pregnancy test (if of childbearing age) - The tumor to be treated has not been previously irradiated **You may NOT be eligible if...** - Your vulvar cancer is not squamous cell type - You have previously had radiation to the vulva, groin, or pelvis - Your metastasis is limited to pelvic lymph nodes only and surgery with curative intent is still possible Talk to your doctor to see if this trial is right for you.