Nelfinavir, Cisplatin, and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by Surgery

This study is testing whether adding nelfinavir (an antiviral drug) to standard chemotherapy and radiation improves treatment for vulvar cancer that cannot be removed surgically. **You may be eligible if...** - You have a confirmed diagnosis of invasive vulvar cancer that cannot be surgically removed - Your cancer is stage T2–T4 (locally advanced) - You have adequate blood counts, kidney, and liver function - You have not had prior radiation to the pelvis for this cancer **You may NOT be eligible if...** - Your cancer has spread to distant organs (metastatic) - You have serious infections (e.g., active hepatitis, HIV with low CD4 count) - You are pregnant or breastfeeding - You have severe neuropathy (nerve damage) or uncontrolled diabetes - You are taking certain medications that interact with nelfinavir Talk to your doctor to see if this trial is right for you.