RecruitingNot ApplicableNCT04187820

Effect of Acupuncture on Mild to Moderate Active Crohn's Disease

Effect of Acupuncture on Crohn's Disease Via the Regulation of Trp-kyn Metabolism in Brain-gut Axis


Sponsor

Shanghai Institute of Acupuncture, Moxibustion and Meridian

Enrollment

60 participants

Start Date

Jun 1, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

To observe the clinical effect of acupuncture on Crohn's disease (CD) and its influence on brain function activity and the TRY-KYN metabolism level, and to screen the brain image markers of acupuncture on CD


Eligibility

Min Age: 16 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether acupuncture can reduce symptoms and inflammation in people with mild-to-moderate active Crohn's disease, particularly for patients who have not responded to or cannot tolerate standard drug treatments. **You may be eligible if...** - You are 16–70 years old - You have been diagnosed with Crohn's disease with mild to moderate active disease (CDAI score 150–450) - Standard medications have not worked for you, or you were intolerant or declined them (including mesalazine, steroids, immunomodulators, or anti-TNF drugs) **You may NOT be eligible if...** - Your Crohn's disease is severe (CDAI 450 or above) - You are on multiple strong medications that would confound the results - You have had recent bowel surgery or have abscesses/fistulas - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERacupuncture

Patients receiving acupuncture and mild moxibustion, whom were treated 3 times per week for 12 weeks and followed up for 36 weeks. CV12 and Bilateral ST37, SP6, SP4, LR3, KI3, LI4 and LI11 were selected for acupuncture and bilateral ST25 and ST36 were selected for moxibustion. In the acupuncture group, Hwato acupuncture device was used to blind the subjects, and had the deqi sensation. The surface temperature of acupoints was maintained at 43℃± 1℃ for moxibustIon.


Locations(2)

Shanghai Research Institute of Acupuncture and Meridian

Shanghai, Shanghai Municipality, China

Guona Li

Shanghai, China

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NCT04187820


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