Treatment of Locally Advanced VULvar CArcinoma in a Neoadjuvant Setting With Carboplatin and Paclitaxel Chemotherapy (VULCANize)

This study is testing whether chemotherapy (carboplatin and paclitaxel) given before surgery can shrink locally advanced vulvar cancer enough to allow for less extensive surgery and better outcomes. **You may be eligible if...** - You are a woman aged 18 or older - You have been diagnosed with squamous cell vulvar cancer confirmed by biopsy - Your cancer is at stage T2 without distant spread - Your general health status is good enough to tolerate treatment (WHO performance status 0–2) - Your blood, liver, and kidney functions are adequate - You have a negative pregnancy test if you could become pregnant **You may NOT be eligible if...** - Your vulvar cancer is a type other than squamous cell carcinoma - You have had radiation therapy to the vulva, groin, or pelvis before - Your cancer has spread only to pelvic lymph nodes and surgery with curative intent is still possible - You have had another cancer in the past 5 years Talk to your doctor to see if this trial is right for you.