Optimization of a Non-invasive Electrophysiological Method for Studying the Functionality of Auditory Nerve Fibers
University Hospital, Clermont-Ferrand
430 participants
Apr 29, 2019
INTERVENTIONAL
Conditions
Summary
Acoustic overexposure can induced temporary or hearing loss. Usually hearing loss is associated with cochlear cell damages. Recently, a new pathological entity was described and called "hidden hearing loss". In animal model, the histopathology revealed a selective reduction in the number of auditory fibers, resulting in a decrease in the amplitude of wave I of the auditory brainstem response. Electrocochleography (Ecog) is a method for recording the electrical potentials of the cochlea (e.g. wave I). In clinical routine, Ecog is performed invasively with sedation or local anesthesia. Actually, a non invasive approach could be perform but it seems necessary to optimize this method and to define reference values in healthy volunteers.
Eligibility
Inclusion Criteria4
- Between 18 and 55 years old
- be affiliated to a social security system
- understand (oral and written) of the French language
- be a qualified hearing with normal tympanogram and audiogram
Exclusion Criteria7
- have a complaint of hearing
- have a exposure to noise (professional and/or activities)
- refusal to participate in the study
- have ear infections and/or ENT medical history
- have cardiovascular, metabolic, neurological and psychiatric desease
- being a protected person
- healthy volunteer who has received compensation equal to or greader than 4500€ in clinical study
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Electrocochleography is a technique that analyses the functionality of inner ear.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04198909