RecruitingNot ApplicableNCT04200768

FATLAS: Comprehensive Multi-level Characterization of Systemic and Mammary Adiposity in Breast Cancer Patients.

Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

150 participants

Start Date

Sep 1, 2020

Study Type

INTERVENTIONAL

Conditions

Breast Neoplasms

Summary

FATLAS is a prospective, interventional, non Investigational Medicinal Product (IMP) study aiming to characterize the micro- and macroenvironment of breast cancer according to patient adiposity in different histological and molecular subtypes. The macroscopic profiling of the patient's adiposity will be based on Body Mass Index (BMI), bioimpedance analysis and waist-to-hip ratio. Blood samples will be taken for lipidomic analyses and for hormonal and immuno assays. Microscopic profiling of adiposity and inflammation will be done on fresh frozen (FF) and Formalin-Fixed Paraffin-Embedded (FFPE) samples from the tumour resection specimen and will consist of histological characterization, immuno assays, multiplex immunohistochemistry, DNA sequencing and single nuclei RNA sequencing both in the tumour and in adjacent normal mammary tissue.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting detailed biological samples (blood, tissue) and body measurements from breast cancer patients to understand how body weight and fat tissue interact with different types of breast cancer, helping explain why obesity affects breast cancer outcomes. **You may be eligible if...** - You have been diagnosed with invasive ductal carcinoma, invasive lobular carcinoma, or inflammatory breast cancer confirmed by biopsy - Your cancer is stage I, II, or III (not metastatic) - You are willing to provide blood and tissue samples - Men with any type of breast cancer are also eligible **You may NOT be eligible if...** - Your cancer has spread to distant organs (stage IV) - You are unwilling to provide tissue or blood samples - You cannot provide written informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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