Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths
Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths (DEFI-2)
University Hospital, Brest
200 participants
Oct 5, 2020
INTERVENTIONAL
Conditions
Summary
The DEFI-1 study recruited 625 women witnesses and 299 of their spouses. With regard to case couples, 271 cases were recruited from the spontaneous repeated miscarriages (SRM) subgroup (≥3 spontaneous miscarriage (SM) from trimester 1 of pregnancy) and 93 from the unexplained fetal death in utero (FDIU) subgroup from trimesters 2 and 3 of pregnancy. The main objective of the DEFI 2 study is to increase the number of case-pairs in these 2 particular subgroups to replicate the results of the genetic determinants highlighted from cases and controls with extreme phenotypes and obtain a sufficient number of women with FDIUs to identify specific determinants.
Eligibility
Inclusion Criteria5
- couples whose wife is over 18 and under 40 inclusive,
- couples having undergone at least 3 unexplained SM in the first trimester or an FDIU in the trimesters 2 and 3 of pregnancy (excluding funicular and fetal causes and proven preeclampsia)
- the man must be over 18 years old.
- each member of the couple must consent to the investigation.
- Subjects benefiting from a social security scheme.
Exclusion Criteria9
- couples where the woman is under 18 or over 40,
- couples whose man is under 18,
- identified cause of SRM or FDIU
- Inability to consent for one of the members of the couple,
- refusal to participate for one of the members of the couple.
- treatment with anticoagulants or anti-aggregating platelet for women.
- Person under legal protection
- Subjects not benefiting from a social security scheme
- Refusal to participate
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Interventions
biological samples will be taken from the subjects included
Locations(1)
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NCT04207814