RecruitingPhase 2Phase 3NCT04209868

Preoperative Paravertebral Block in Cancer Surgery of the Lung

Preoperative Paravertebral Block in Cancer Surgery of the Lung: ParaSOL a Prospective Randomized Controlled Clinical Trial


Sponsor

Guy's and St Thomas' NHS Foundation Trust

Enrollment

100 participants

Start Date

Feb 1, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators aim to determine whether ultrasound-guided preemptive paravertebral blockade (PVB) local anaesthetic (pre-PVB LA), administered in addition to the post-operative PVB (post-PVB) local anaesthetic (LA) infusion, reduces acute postoperative pain, opioid requirement, chronic pain, and improves surgical recovery, in thoracoscopic surgery for lung cancer.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating whether a nerve block (paravertebral block) given before lung cancer surgery helps reduce pain after the operation compared to standard pain management, specifically in patients having minimally invasive (VATS) lung surgery. **You may be eligible if...** - You are 18 or older - You are scheduled for elective lung cancer surgery to remove one lobe of the lung using minimally invasive (VATS) technique - Your overall health is rated ASA I to III by your anesthesiologist **You may NOT be eligible if...** - You are planned for open chest surgery, a larger lung removal (bilobectomy, pneumonectomy), or other chest procedures - You are allergic to local anesthetics or opioids - You have a blood clotting disorder - You have pre-existing chest pain or chronic pain conditions - You have had previous lung surgery - You have another surgery planned within 3 months of this one Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLevo-Bupivacaine Hydrochloride (HCl) 0.5 % in 20mL Injection

As per arm description

DRUG0.9% Sodium Chloride 20mL Injection

As per arm description


Locations(1)

Guy's Hospital, Great Maze Pond

London, United Kingdom

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NCT04209868


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