RecruitingPhase 2Phase 3NCT04209868

Preoperative Paravertebral Block in Cancer Surgery of the Lung

Preoperative Paravertebral Block in Cancer Surgery of the Lung: ParaSOL a Prospective Randomized Controlled Clinical Trial

Sponsor

Guy's and St Thomas' NHS Foundation Trust

Enrollment

100 participants

Start Date

Feb 1, 2019

Study Type

INTERVENTIONAL

Conditions

Thoracic Neoplasm Chronic Pain Post-Procedural Acute Post-thoracotomy Pain Anesthesia, Local

Summary

The investigators aim to determine whether ultrasound-guided preemptive paravertebral blockade (PVB) local anaesthetic (pre-PVB LA), administered in addition to the post-operative PVB (post-PVB) local anaesthetic (LA) infusion, reduces acute postoperative pain, opioid requirement, chronic pain, and improves surgical recovery, in thoracoscopic surgery for lung cancer.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Elective radical primary lung cancer VATS surgery for single lobectomy
American Society of Anesthesiology (ASA) I-III
Age ≥18

Exclusion Criteria8

Planned open thoracotomy, wedge resection, bilobectomy, pneumonectomy, chest wall resection or total pleurectomy
Local anaesthetic or opioid allergy
Coagulation disorders
Inability to comply with study questionnaire completion
Pre-existing pain in chest area or pre-existing pain conditions
Local infection/tumour at proposed PVB site
Previous lung surgery
Planned surgery within 3 months of the primary lung resection

Interventions

DRUGLevo-Bupivacaine Hydrochloride (HCl) 0.5 % in 20mL Injection

As per arm description

DRUG0.9% Sodium Chloride 20mL Injection

As per arm description

Locations(1)

Guy's Hospital, Great Maze Pond

London, United Kingdom

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NCT04209868