RecruitingPhase 2NCT04212715

Prostate SABR With Intra-Prostatic SABR Boost

Prostate SABR With Intra-Prostatic SABR Boost: A Phase II Study


Sponsor

King Saud University

Enrollment

30 participants

Start Date

Dec 26, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

Stereotactic Ablative Radiation (SABR/SBRT) will be prescribed to a dose of 35 Gy in 5 fractions, once weekly to prostate with a simultaneous intra-prostatic boost to the MR detected nodule up to 50Gy. The pelvic lymph nodes and seminal vesicles will also receive 25 Gy in 5 weekly fractions.


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a radiation therapy approach called SABR (stereotactic ablative radiotherapy) for prostate cancer that delivers an extra high dose (boost) to the area inside the prostate where the cancer is most concentrated, to improve cancer control. **You may be eligible if...** - You have been diagnosed with prostate cancer confirmed by biopsy (adenocarcinoma) - Your cancer is classified as high-risk (at least one of: stage T3, Gleason score 8–10, or PSA above 20 ng/mL) - You are willing to provide informed consent **You may NOT be eligible if...** - You have had radiation therapy to the pelvis before - You have conditions that make radical prostate radiation unsafe (e.g., connective tissue disease, inflammatory bowel disease) - You cannot have a prostate MRI - Your prostate cancer has clearly spread to lymph nodes outside the pelvis or to other parts of the body Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONPelvic SABR with intra-prostatic SABR

SABR 25Gy / 5 fractions to pelvis; 35Gy / 5 fractions to prostate; up to 50Gy / 5 fractions to MR nodule


Locations(1)

King Saud University Medical City

Riyadh, Saudi Arabia

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NCT04212715


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