Single- vs. Two-Fraction Spine Stereotactic Radiosurgery for the Treatment of Vertebral Metastases
Case Comprehensive Cancer Center
130 participants
Feb 7, 2020
INTERVENTIONAL
Conditions
Summary
Spine radiosurgery (SRS) utilizes advanced treatment planning with focused x-rays to deliver one to four high dose treatments to the spine to help relieve pain and/or neurologic symptoms. Spine SRS uses special equipment to position the participant and guide the focused beams toward the area to be treated and away from normal tissue. One of the side effects of spine SRS is the development of vertebral compression fractures, many of which are not painful. The goal of this study is to compare the effects, good and/or bad, of spine SRS given in 1 or 2 treatments. Our main goal is to find out which approach will reduce the chances of developing vertebral compression fractures.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Diagnostic MRI
Planning MRI: high definition (HD) MRI of the region of interest (1 vertebral level above and below the level(s) being treated)
Simulation CT is obtained (1.5 mm slice thickness)
QOL assessment
Brief pain inventory (BPI), including narcotic assessment
sSRS 18 Gy in 1 fraction
sSRS 24 Gy in 2 fractions to be delivered either on consecutive days or one day apart.
Locations(1)
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NCT04218617