RecruitingNot ApplicableNCT04220047

Effects of Left Atrial Appendage Resection and Marshall Ligament Amputation on Clinical Outcome in Patients Undergoing Off-pump Coronary Artery Bypass

Fuwai Hospital, Chinese Academy of Medical Science

Sponsor

China National Center for Cardiovascular Diseases

Enrollment

400 participants

Start Date

Apr 30, 2020

Study Type

INTERVENTIONAL

Conditions

Atrial Fibrillation Stroke Coronary Artery Disease

Summary

Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative atrial fibrillation.New-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term and long term risk of stroke and mortality.Marshall ligament amputation may reduce the occurence of atrial fibrillation. However, little is known whether this approach is justified during the coronary artery bypass graft.Therefore, this study aimed to investigate whether LAAO and Marshall ligament amputation during off-pump coronary artery bypass was associated with reduced risks of postoperative new-onset atrial fibrillation and stroke.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether surgically removing the left atrial appendage (a small pouch in the heart) and cutting a specific heart ligament during bypass surgery can help prevent atrial fibrillation (an irregular heartbeat) from developing after the operation. **You may be eligible if...** - You are undergoing your first off-pump coronary artery bypass surgery (heart bypass surgery without a heart-lung machine) - This is an isolated procedure (bypass only, no other heart procedures at the same time) **You may NOT be eligible if...** - You already have atrial fibrillation or a history of atrial fibrillation - You are having additional heart or non-heart surgeries at the same time - Your surgery needs to be converted to on-pump bypass during the procedure - This is an emergency surgery - You have had previous heart surgery - You have severe organ dysfunction Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURELeft Atrial Appendage Resection and Marshall Ligament Amputation

Left Atrial Appendage Resection and Marshall Ligament Amputation during the cardiac surgery

Locations(1)

Fuwai Hospital

Beijing, China

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NCT04220047

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