RecruitingNot ApplicableNCT04220047

Effects of Left Atrial Appendage Resection and Marshall Ligament Amputation on Clinical Outcome in Patients Undergoing Off-pump Coronary Artery Bypass

Fuwai Hospital, Chinese Academy of Medical Science


Sponsor

China National Center for Cardiovascular Diseases

Enrollment

400 participants

Start Date

Apr 30, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative atrial fibrillation.New-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term and long term risk of stroke and mortality.Marshall ligament amputation may reduce the occurence of atrial fibrillation. However, little is known whether this approach is justified during the coronary artery bypass graft.Therefore, this study aimed to investigate whether LAAO and Marshall ligament amputation during off-pump coronary artery bypass was associated with reduced risks of postoperative new-onset atrial fibrillation and stroke.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria1

  • isolated first off-pump coronary artery bypass

Exclusion Criteria6

  • Preoperative atrial fibrillation or a history of atrial fibrillation;
  • Concurrent cardiac or non-cardiac surgery
  • Intraoperative convert to bypass bypass surgery
  • Emergency surgery
  • History of previous cardiac surgery
  • Severe organ dysfunction

Interventions

PROCEDURELeft Atrial Appendage Resection and Marshall Ligament Amputation

Left Atrial Appendage Resection and Marshall Ligament Amputation during the cardiac surgery


Locations(1)

Fuwai Hospital

Beijing, China

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NCT04220047


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