Coronary Artery Disease Clinical Trials

379 recruitingLast updated: May 4, 2026

Coronary Artery Disease Trials at a Glance

412 actively recruiting trials for coronary artery disease are listed on ClinicalTrialsFinder across 6 cities in 59 countries. The largest study group is Not Applicable with 158 trials, with the heaviest enrollment activity in Seoul, Barcelona, and New York. Lead sponsors running coronary artery disease studies include Fundación EPIC, Seung-Jung Park, and China National Center for Cardiovascular Diseases.

Browse coronary artery disease trials by phase

Treatments under study

About Coronary Artery Disease Clinical Trials

Looking for clinical trials for Coronary Artery Disease? There are currently 379 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Coronary Artery Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Coronary Artery Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 412 trials

Recruiting

Coroflex® ISAR NEO PMCF Study

Coronary Artery Disease (CAD)Ischemic Heart Disease
Fundación EPIC3,000 enrolled22 locationsNCT05698732
Recruiting
Not Applicable

Trial of Orbital Atherectomy Versus Standard Strategy in Calcified Bifurcation Lesions

Coronary DiseaseCoronary Artery Disease
Fundación EPIC200 enrolled8 locationsNCT06736899
Recruiting
Not Applicable

Hybrid Percutaneous Coronary Intervention Combining a Bioresorbable Scaffold With Drug-coated Balloons Versus a Conventional Drug-eluting Stent-based Strategy in Patients With Long and Diffuse Coronary Artery Disease

Coronary Artery DiseasePercutaneous Coronary Intervention (PCI)Diffuse Coronary Artery Disease
University Hospital, Geneva150 enrolled1 locationNCT06710210
Recruiting
Not Applicable

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

Coronary Artery Disease
Sunnybrook Health Sciences Centre754 enrolled43 locationsNCT05427370
Recruiting

Scaffold in Emilia Romagna and in the MAGIC Network

Coronary Artery Disease
University Hospital of Ferrara1,111 enrolled17 locationsNCT03327961
Recruiting

REGistry of Long-term AnTithrombotic TherApy-1

Peripheral Artery DiseaseCoronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
National Medical Research Center for Cardiology, Ministry of Health of Russian Federation2,000 enrolled1 locationNCT04347200
Recruiting
Phase 2

A Study of SRSD107 in Participants With Chronic Coronary and/or Peripheral Arterial Disease

Peripheral Arterial DiseaseCoronary Artery Disease (CAD)
Sirius Therapeutics Co., Ltd.104 enrolled1 locationNCT07318155
Recruiting
Not Applicable

Timing of FFR-guided PCI for Non-IRA in NSTEMI and MVD (OPTION-NSTEMI)

Myocardial Infarction, AcuteMulti Vessel Coronary Artery DiseaseMulti-Vessel Coronary Artery Stenosis
Chonnam National University Hospital1,014 enrolled1 locationNCT04968808
Recruiting

S-FLEX Netherlands Registry: Prospective Evaluation of the Supraflex Family Sirolimus-eluting Coronary Stent System

Coronary Artery Disease
Sahajanand Medical Technologies Limited10,000 enrolled7 locationsNCT03443999
Recruiting

Sequent Extended Study

Coronary Artery DiseaseIschemic Heart Disease
Fundación EPIC2,028 enrolled27 locationsNCT05788432
Recruiting
Not Applicable

Prevail Global Study

Coronary Artery Disease
Medtronic Vascular1,205 enrolled51 locationsNCT06535854
Recruiting

Ultrathin Strut Sirolimus-eluting Stent With Bioabsorbable Polymer in Patients Receiving Chronic Oral Anticoagulation

Coronary Artery DiseaseIschemic Heart Disease
Fundación EPIC500 enrolled10 locationsNCT06863155
Recruiting
Not Applicable

Artificial Intelligence-Driven Medipixel Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI Trial (AIM-FFR Trial)

Acute Coronary SyndromeCoronary Artery DiseaseChronic Coronary Syndrome
Samsung Medical Center2,100 enrolled23 locationsNCT07329699
Recruiting
Not Applicable

Strategic Comparison Of Ischemia-based Versus Plaque Burden and vulnErability-based Revascularization in High-Risk Coronary Artery Disease Patients

Coronary Artery Disease
Bon-Kwon Koo1,944 enrolled1 locationNCT07324720
Recruiting
Phase 4

The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial

Coronary Artery Disease
VA Office of Research and Development700 enrolled9 locationsNCT05618353
Recruiting
Not Applicable

Randomization of Single vs Multiple Arterial Grafts

Heart DiseasesCoronary Artery Disease
Weill Medical College of Cornell University4,300 enrolled59 locationsNCT03217006
Recruiting

Evaluation of a Diagnostic Software for Coronary Artery Disease Using Retrospective CCTA Data (CODEX-1 Study)

AtherosclerosisMyocardial IschemiaCoronary Artery Disease
Instituto de Investigación Biomédica de Salamanca1,000 enrolled4 locationsNCT06977295
Recruiting

PREVAIL Paclitaxel-coated Balloon in Small Coronary Disease and High-bleeding Risk Patients

Coronary Artery Disease
Fundación EPIC501 enrolled18 locationsNCT06321757
Recruiting

Vascular Senescence and Atherosclerotic Plaque Vulnerability

Coronary Artery Disease
Niguarda Hospital300 enrolled1 locationNCT06313645
Recruiting

Minimally Invasive Coronary Artery Bypass Supported by Cangrelor

Coronary Artery DiseaseAntiplatelet TherapyMinimally Invasive Coronary Revascularization Surgery
Cardiocentro Ticino30 enrolled1 locationNCT07514962