Video-assisted Thoracoscopic Thymectomy Versus Subxiphoid Procedure

This study compares two surgical approaches for removing the thymus gland — a small organ in the chest that plays a role in immune function. Thymectomy (thymus removal) is performed for thymoma (a tumor of the thymus) and for myasthenia gravis (an autoimmune disease causing muscle weakness). The two approaches compared are video-assisted thoracoscopic surgery (VATS), which uses small incisions and a camera through the chest, versus the subxiphoid approach, which goes through a single incision below the breastbone. Both are minimally invasive techniques, but the subxiphoid approach is newer. The study aims to determine which approach offers better surgical outcomes, fewer complications, and faster recovery for patients. You may be eligible if: - You are between 20 and 80 years old - You have been diagnosed with thymoma (with or without myasthenia gravis) - OR you have generalized myasthenia gravis that has not responded to medication - You have adequate heart and lung function to tolerate surgery You may NOT be eligible if: - Your heart or lung function is too poor for surgery - You have generalized myasthenia gravis with MuSK antibodies (a specific subtype) Talk to your doctor to see if this trial is right for you.