RecruitingNot ApplicableNCT04225975

Neonate Cerebral Activity in Immediate Post Partum

Evaluation of Cerebral, Hemodynamic and Neuronal Activities in Neonates in the Immediate Postpartum


Sponsor

Centre Hospitalier Universitaire, Amiens

Enrollment

60 participants

Start Date

Mar 3, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Neonatal anoxia-ischemia causes significant neurodevelopmental disorders. In this study the investigators want to better understand the interactions between the nervous and the hemodynamic cerebral systems during the adaptation of the neonate to ectopic life just after birth. Birth is an at risk situation of neonatal anoxic ischemia and the lack of objective criteria for cerebral tissue oxygenation has consequences on neuronal activity. Ph cord analysis is inadequate and only indirectly reflects the state of cerebral oxygenation. Both neuronal and vascular systems are part of the same functional entity and the analysis of their interactions is likely to reveal some early malfunctions of these networks. In this study, the investigators want to develop a multi-scale, multimodal approach that allows simultaneous interrogation of both neuronal and vascular compartments during the 15 minutes after delivery. The investigators will record, with the aid of a single sensor placed on the scalp of the child, the electroencephalogram and the cerebral tissue oxygenation. The investigators will measure interactions by means of correlation analysis between both signals.


Eligibility

Min Age: 1 MinuteMax Age: 15 Minutes

Inclusion Criteria1

  • Full term neonates between 36 and 41 weeks Gestational Age

Exclusion Criteria5

  • Premature neonates
  • Neonates of twin pregnancy
  • Suspicion of congenital malformation seen in antenatal ultrasound
  • Any pathology requiring pediatric care from birth
  • Newborns whose mothers had a chronic viral infection such as AIDS, hepatitis B or C, or who had a multidrug-resistant bacteria

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Interventions

DIAGNOSTIC_TESTelectroencephalogram

Within the 5 min after birth the electroencephalogram of the neonates will be recorded with the aid of a patch on the scalp

DIAGNOSTIC_TESToxymetry

Within the 5 min after birth the cerebral oxymetry of the neonates will be recorded with the aid of a patch on the scalp


Locations(1)

CHU Amiens

Amiens, France

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NCT04225975


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