Salvage HDR for Locally Recurrent Prostate Cancer

This study is testing a targeted radiation treatment (high-dose brachytherapy) to re-treat prostate cancer that has returned locally after a patient previously received radiation for prostate cancer. **You may be eligible if...** - You are a man who previously received radiation therapy (external beam or brachytherapy) for prostate cancer - At least 2 years have passed since your original radiation treatment - Your PSA (a prostate cancer marker in blood) has risen and imaging confirms the cancer has returned locally in the prostate, with no spread to lymph nodes or other organs - Your cancer was confirmed by biopsy through MRI guidance - You are not currently on hormone therapy - Your overall health and urinary function are reasonably good - Your life expectancy is more than 5 years **You may NOT be eligible if...** - Your cancer has spread beyond the prostate - You have inflammatory bowel disease - You have severe pre-existing urinary symptoms - You have a condition that prevents MRI or anesthesia - Your kidney function is poor Talk to your doctor to see if this trial is right for you.