RecruitingNCT04262830

Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure

CATCH-HF: Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure


Sponsor

Hari Narayan

Enrollment

150 participants

Start Date

Sep 30, 2019

Study Type

OBSERVATIONAL

Conditions

Summary

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.


Eligibility

Min Age: 13 YearsMax Age: 39 Years

Plain Language Summary

Simplified for easier understanding

This study is using advanced heart imaging (including cardiac MRI) in people who were treated for childhood cancer with a type of chemotherapy called anthracyclines (e.g., doxorubicin), to detect early signs of heart damage before symptoms of heart failure develop. **You may be eligible if:** - You are between 13 and 39 years old - You were diagnosed with cancer before age 22 - You received anthracycline chemotherapy and it has been at least two years since your cancer diagnosis **You may NOT be eligible if:** - You have a metallic implant (like a pacemaker or certain surgical clips) that is not compatible with MRI - You have a history of significant congenital heart disease - You are pregnant at the time of enrollment - You have a medical or psychiatric condition that would prevent you from completing the heart MRI safely without sedation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTCardiac magnetic resonance imaging (MRI)

Cardiac magnetic resonance imaging will be performed to evaluate cardiac remodeling, function, and tissue characteristics

OTHERAccelerometer physical activity monitoring

Measurement of physical activity using hip-worn accelerometer.


Locations(1)

Rady Children's Hospital

San Diego, California, United States

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NCT04262830


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