Low Dose IL-2 for the Treatment of Crohn's Disease

This study is testing whether low doses of interleukin-2 (IL-2), a protein that regulates the immune system, can treat moderate-to-severe Crohn's disease — a chronic inflammatory bowel disease — by boosting the immune cells that calm inflammation. **You may be eligible if:** - You are between 12 and 80 years old (note: enrollment at some centers is limited to age 30 and under) - You have a confirmed diagnosis of Crohn's disease - Your disease is moderate to severe based on standard scoring - Endoscopy (colonoscopy) confirms active inflammation in your bowel - You have tried and failed other standard Crohn's treatments **You may NOT be eligible if:** - You have active infection, cancer, or significant immune system problems - You are pregnant or breastfeeding - You have certain serious complications of Crohn's requiring immediate surgery Talk to your doctor to see if this trial is right for you.