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RecruitingPhase 4NCT04263922

Huaiqihuang Granule in the Treatment of Primary Glomerulonephritis of Stage CKD3

Huaiqihuang Granules in the Treatment of Primary Glomerulonephritis of Stage CKD3: a Randomized, Double-blind, Double-simulation, Positive Parallel Control Multi-center Clinical Study

Sponsor

The First Affiliated Hospital of Dalian Medical University

Enrollment

466 participants

Start Date

Jun 30, 2020

Study Type

INTERVENTIONAL

Conditions

Renal Insufficiency, Chronic

Summary

This is a multicentre prospective, randomized, double-blind and imitation, positive-drug parallel controlled clinical trail. The objective of this study is to evaluate the efficacy and safety of Huaiqihuang Granule in patients with CKD stage 3 primary glomerulonephritis.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a traditional Chinese herbal medicine called Huaiqihuang granule can slow the progression of chronic kidney disease (stage 3) caused by primary glomerulonephritis, a condition where the kidneys' filtering units are inflamed. **You may be eligible if:** - You are between 18 and 65 years old - You have been diagnosed with primary glomerulonephritis by kidney biopsy - Your kidney function is in the moderate impairment range (eGFR 30–60 ml/min) - Your 24-hour urine protein is 2.0g or less - Your blood pressure is controlled at or below 140/90 mmHg **You may NOT be eligible if:** - Your kidney disease is caused by another condition (secondary glomerulonephritis) - You have recently taken corticosteroids, immunosuppressants, or certain blood pressure medications without a two-week washout period - You are pregnant, breastfeeding, or planning to become pregnant - You have dangerously high potassium levels or severe low blood pressure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHuaiqihuang granules

Huaiqihuang granules, 2 bags at a time, 3 times a day. Valsartan capsule simulant, 80mg at a time, once a day. Oral administration.

DRUGValsartan capsule

Valsartan capsule, 80mg at a time, once a day. Huaiqihuang granules simulant, 2 bags at a time, 3 times a day. Oral administration.

Locations(34)

Beijing Hospital

Beijing, Beijing Municipality, China

Lanzhou University Second Hospital

Lanzhou, Gansu, China

The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China

The Fourth Hospital of Hebei Medical University

Shijiazhuang, Hebei, China

The First Affiliated Hospital of Hebei North University

Zhangjiakou, Hebei, China

The 2nd Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

Henan Provincial people's Hospital

Zhengzhou, Henan, China

Xiangya Hospital of Central South University

Changsha, Hunan, China

The first affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology

Baotou, Inner Mongolia, China

Affiliated Hospital of Chifeng University

Chifeng, Inner Mongolia, China

Changzhou NO.2 People's Hospital

Changzhou, Jiangsu, China

Jiangsu Province Hospital of Chinese Medicine

Nanjing, Jiangsu, China

The First Bethune Hospital of Jilin University

Changchun, Jilin, China

The Second Hospital of Jilin University

Changchun, Jilin, China

Anshan Central Hospital

Anshan, Liaoning, China

Anshan Shuangshan Hospital

Anshan, Liaoning, China

Ansteel Group General Hospital

Anshan, Liaoning, China

Benxi Iron and Steel General Hospital of Liaoning Health Industry Group

Benxi, Liaoning, China

The First Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China

Dalian Ruikaier Nephropathy Hospital

Dalian, Liaoning, China

Shengjing Hospital of China Medical University( Huaxiang Area)

Shenyang, Liaoning, China

The First Hospital of China Medical University

Shenyang, Liaoning, China

Central Hospital affiliated to Shenyang Medical College

Shenyang, Liaoning, China

Shengjing Hospital of China Medical University (Nanhu Area)

Shenyang, Liaoning, China

Yingkou Central Hospital

Yingkou, Liaoning, China

General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China

Qilu Hospital of Shandong University

Jinan, Shandong, China

The Sixth People's Hospital affiliated to Shanghai Jiaotong University

Shanghai, Shanghai Municipality, China

Xinhua Hospital Affiliated to Shanghai Jiaotong University School of medicine

Shanghai, Shanghai Municipality, China

Second Hospital of Shanxi Medical University

Taiyuan, Shanxi, China

Shanxi Provincial people's Hospital

Taiyuan, Shanxi, China

The Second Hospital of Tianjin Medical University

Tianjin, Tianjin Municipality, China

Kunming Yan'an Hospital

Kunming, Yunnan, China

Zhejiang Provincial people's Hospital

Hangzhou, Zhejiang, China

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