RecruitingPhase 3NCT04274179

Ketogenic Diet for New-Onset Absence Epilepsy

A Prospective, Case-control Evaluation of Ketogenic Dietary Therapy for New-onset Childhood Absence Epilepsy


Sponsor

Johns Hopkins University

Enrollment

40 participants

Start Date

Aug 10, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The ketogenic diet is a medical therapy for epilepsy that is used nearly predominantly for refractory epilepsy (after 2-3 drugs have been tried and failed). However, there is both published evidence for first-line use (infantile spasms, Glut1 deficiency syndrome) and also anecdotal experience (families choosing to change the child's (or the family' own) diet rather than use anticonvulsant medications). Childhood absence epilepsy (refractory) has been published as being responsive to ketogenic diet therapy by the investigators' group previously. This is a small, prospective, 3 month trial to assess if using a modified Atkins diet is a feasible and effective option for new-onset childhood absence epilepsy. The investigators will compare to a group of children in which the parents have declined and chose to start anticonvulsant medications.


Eligibility

Min Age: 3 YearsMax Age: 12 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Absence epilepsy medications and Modified Atkins Diet for people with epilepsy, absence, ketogenic dieting, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 3 Years to 12 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERModified Atkins Diet

Low carb (20g/day), high fat, moderate protein diet. Started as an outpatient in clinic.

DRUGAbsence epilepsy medications

At neurologist's discretion. \*OF NOTE\< THIS ARM IS COMPLETED


Locations(1)

Johns Hopkins Hospital

Baltimore, Maryland, United States

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NCT04274179


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