RecruitingPhase 3NCT04284839

The Direct Oral Anticoagulation Versus Vitamin K Antagonist After Cardiac Surgery Trial

Sponsor

Population Health Research Institute

Enrollment

3,500 participants

Start Date

Jul 18, 2021

Study Type

INTERVENTIONAL

Conditions

Bleeding Post Cardiac Surgery Indication for Anticoagulation

Summary

The DANCE Trial is a multi-centre, randomized controlled trial comparing the safety of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) in the early period (30 days) after cardiac surgery in patients with atrial fibrillation requiring oral anticoagulation.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called DOAC and a drug called VKA for people with bleeding post cardiac surgery and indication for anticoagulation. The study is currently recruiting participants at 19 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDOAC

Patients will receive a DOAC at doses recommended for the indication, adjusted for their renal function is required. The choice of DOAC will be at the discretion of the treating physician.

DRUGVKA

Patients in the control group will receive VKA once daily; the individual dose will be titrated to achieve a guideline-recommended INR range.

Locations(19)

St Vincent's Hospital Melbourne

Fitzroy, Victoria, Australia

Royal Melbourne Hospital, University of Melbourne

Parkville, Victoria, Australia

University of Alberta Hospital

Edmonton, Alberta, Canada

University of British Columbia

Vancouver, British Columbia, Canada

St. Boniface Hospital

Winnipeg, Manitoba, Canada

Saint John Regional Hospital

Saint John, New Brunswick, Canada

Health Science Centre

St. John's, Newfoundland and Labrador, Canada

Health Sciences North Research Institute

Greater Sudbury, Ontario, Canada

Hamilton General Hospital

Hamilton, Ontario, Canada

Sunnybrook Hospital

Toronto, Ontario, Canada

Toronto General Hospital

Toronto, Ontario, Canada

Montreal Heart Institute

Montreal, Quebec, Canada

Hôpital Sacré-Coeur de Montréal

Montreal, Quebec, Canada

IUCPQ-ULaval

Québec, Quebec, Canada

Heart Center Leipzig

Leipzig, Saxony, Germany

University Hospital Jena

Jena, Thuringia, Germany

University Hospital Bonn Heart Center

Bonn, Germany

West-German Heart and Vascular Center, University of Duisburg-Essen

Essen, Germany

University Medical Center Hamburg-Eppendorf

Hamburg, Germany

View Full Details on ClinicalTrials.gov

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NCT04284839