RecruitingNCT04288674

Leptospirosis Registry - LeptoScope

Sponsor

University of Cologne

Enrollment

200 participants

Start Date

Mar 4, 2020

Study Type

OBSERVATIONAL

Conditions

Leptospirosis

Summary

Leptospirosis is a worldwide zoonotic diseases caused by pathogenic Leptospira spp. Human are accidental hosts, who acquired infections after exposition to animal urine, contaminated water or soil, infected tissue. Incidence of invasive leptospirosis disease causing acute kidney injury, acute respiratory distress syndrome (ARDS), myocarditis, hepatic dysfunction, hemorrhage and multi-organ failure, is globally increasing and there have been frequent outbreak situation throughout the world. Due to increasing outbreak situations and globally chances in species distributions, a worldwide surveillance in epidemiology and species distribution is urgently needed. The objective of the Leptospirosis Registry - LeptoScope is to overcome the lack knowledge on epidemiology, clinical course, prognostic factors and molecular characteristics for invasive leptospirosis disease.

Eligibility

Inclusion Criteria3

Cultural, serological, molecular or histological evidence of invasive leptospirosis diseases
Clinical signs of disseminated leptospirosis disease without cultural, serological, molecular or histological evidence
Case controls: Matching procedures for controls: Particularly, case controls will be included at the same hospitals that conduced cases based on matching of demographics, underlying diseases and duration of hospitalization (i.e. one control per case, both in the same hospital).