RecruitingNot ApplicableNCT04289324

Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants

Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Extremely Preterm Infants - A Single Center Randomized Controlled Trial

Sponsor

Medical University of Vienna

Enrollment

36 participants

Start Date

Feb 25, 2020

Study Type

INTERVENTIONAL

Conditions

Extreme Prematurity High Frequency Oscillation Ventilation Lung Injury, Acute

Summary

To assess whether stepwise oxygenation-guided lung recruitment at regular intervals reduces the oxygen saturation index (OSI = Mean Airway Pressure × Fraction of inspired Oxygen × 100 / peripheral Oxygen Saturation, OSI = MAPxFiO2x100/SpO2) averaged over high frequency oscillation ventilation (HFOV) time in extremely preterm infants.

Eligibility

Max Age: 8 Weeks

Inclusion Criteria3

born below 28 weeks of gestational age
not older than 29 weeks of postmenstrual age
receive HFOV

Exclusion Criteria3

known congenital anomalies of the heart, of the lung, and/or of the central nervous system
known chromosomal abnormalities
participation in other intervention trials

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Interventions

PROCEDUREregular lung recruitment

stepwise oxygenation-guided lung recruitment at regular (twelve hours) intervals during high frequency oscillation ventilation

Locations(1)

Medical University of Vienna

Vienna, State of Vienna, Austria

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NCT04289324

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