Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
An Observational Cross-Sectional Study of Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
National Eye Institute (NEI)
165 participants
Jul 25, 2023
INTERVENTIONAL
Conditions
Summary
Background: The retina is a thin layer of tissue at the back of the eye. Retinal disease usually reduces a person s mobility because it affects how he or she moves through familiar and unfamiliar environments. Researchers want to see if a virtual reality (VR) tool can provide an easier and more accurate way to assess mobility. Objective: To learn if researchers can track changes in mobility in people with retinal disease using a new VR tool. Eligibility: People aged 5 and older with retinal disease that affects their vision, and healthy volunteers. Design: Participants will have 2-3 clinic visits. Participants will wear goggles or sit in front of a screen while sitting. Using a game controller, they will navigate through 4 obstacle courses presented in VR. Participants will have a medical history exam. They will answer questions about their family history. They will fill out questionnaires about the vision and mobility issues they have in their daily lives. Participants will have a complete eye exam. They will read letters from a chart. Their eye pressure will be measured. Their pupils may be dilated with eye drops. Pictures of their eye will be taken. Lights will be shined in their eyes. Participants will take a visual field test. For this, they will look into a dome and press a button when they see a light. Participants will have an electroretinogram. For this, they will sit in the dark with their eyes patched. Then their eyes will be numbed with eye drops and they will wear contact lenses while watching flashing lights. Participants will have optical coherence tomography. This is a noninvasive procedure. It produces cross-sectional pictures of the retina....
Eligibility
Inclusion Criteria12
- For the NEI site: Participant must be five years of age or older.
- For the USyd site: Participant must be thirteen (13) years of age or older.
- Participant (or legal guardian) must understand and be willing to sign the protocol s informed consent document.
- Participant must be able to cooperate with the testing required for this study.
- Participant must be able to read and speak English.
- a. If participant is a minor, their parent or legal guardian must be able to read and speak English.
- For healthy volunteers only:
- Participant must not have retinal disease in either eye.
- Healthy Volunteers Only
- a. Study eye must have visual acuity of 20/20 or better, with or without correction (e.g., glasses or contact lens).
- Participants with Retinal Disease Only
- Study eye must have retinal disease, defined as retinal dysfunction and/or degeneration as previously established by standard clinical methods including perimetry, ERG and imaging.
Exclusion Criteria3
- Participant is in another investigational study and actively receiving study therapy.
- Participant is unable to comply with study procedures.
- STUDY EYE ELIGIBILITY CRITERIA:
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Interventions
Participant wears VR goggles and interacts with a visual avatar via a control unit to navigate four courses. Derived parameters automatically recorded by the VR system include number and type of collisions, walking speed, task time, and distance walked.
Locations(2)
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NCT04289571