Refusal of Breast Surgery in Patients With Breast Cancer With a Clinical Complete Response (cCR) After Neoadjuvant Systemic Therapy and a Confirmed Pathological Complete Response (pCR) Using Vacuum-assisted Biopsy (VAB) and Sentinel Lymph Node Biopsy (SLNB)

This trial is for women with triple-negative or HER2-positive breast cancer who had a complete response to pre-surgery chemotherapy — meaning no visible cancer remained. It tests whether a vacuum-assisted biopsy combined with sentinel lymph node surgery can confirm this complete response so accurately that the main breast surgery (lumpectomy or mastectomy) may be safely skipped. **You may be eligible if...** - You are over 18 years old - You have triple-negative or HER2-positive breast cancer at stage IIA to IIIA - Your cancer responded completely to pre-surgery chemotherapy on imaging - You are in good physical condition (ECOG 0-1) with adequate liver and bone marrow function - Your life expectancy is more than 3 months **You may NOT be eligible if...** - Your cancer did not have a complete response to chemotherapy - You have inflammatory breast cancer or distant metastases - You have contraindications to surgery Talk to your doctor to see if this trial is right for you.