RecruitingPhase 2NCT04295486

Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty

Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For Venous Thromboembolism (VTE) Following Total Joint Arthroplasty - A Multi-center Prospective Randomized Control Trial.

Sponsor

University of Miami

Enrollment

5,478 participants

Start Date

Mar 1, 2021

Study Type

INTERVENTIONAL

Conditions

Venous Thromboembolism

Summary

This research study is attempting to answer the question of whether 81 mg aspirin once daily is as effective as 81 mg aspirin twice daily in preventing blood clots after total joint replacement surgery.

Eligibility

Min Age: 19 Years

Inclusion Criteria2

> 18 years of age
Planning to undergo a primary total hip or knee arthroplasty

Exclusion Criteria11

High risk patients for VTE as defined by:
History of venous thromboembolism
Active malignancy
Known pro thrombotic condition
BMI > 40
Patients requiring anticoagulation for pre-existing conditions
Patients with the contraindication for use of aspirin or nonsteroidal antiinflammatory drugs for reasons such as peptic ulcer disease, intolerance, others.
Patients not fluent in the language of the informed consent form
Prisoners
Pregnancy
Reported to have mental illness or belonging to a vulnerable population