Screening for Occult Malignancy in Patients with Unprovoked Venous Thromboembolism

This study is testing whether a thorough cancer screening (including CT scans, colonoscopy, and other tests) can detect hidden cancers in people who have had an unexplained blood clot (deep vein thrombosis or pulmonary embolism) — since new blood clots without an obvious cause can sometimes be an early sign of cancer. **You may be eligible if...** - You are 50 years old or older - You have been newly diagnosed with a first unprovoked blood clot in a deep vein or lungs (DVT or pulmonary embolism) - Your blood clot has no obvious cause (no recent surgery, immobilization, cancer diagnosis, or other known risk factors) **You may NOT be eligible if...** - You have a known active cancer - You had a blood clot after prolonged bed rest, recent surgery, pregnancy, or other recognized trigger - You recently received hormonal therapy or oral contraceptives - Your overall health status suggests cancer may already be present at the time of the clot Talk to your doctor to see if this trial is right for you.