RecruitingPhase 4NCT04304768

Opioid, HIV and Immune System

Immune Dysfunction in HIV+ Opioid Users

Sponsor

University of Miami

Enrollment

400 participants

Start Date

Nov 18, 2020

Study Type

INTERVENTIONAL

Conditions

Immune Defect

Summary

The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people opioid and non opioid users to understand how opioid affect the immune responses (body defenses against infection) to the flu vaccine.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how opioid use and HIV infection together affect the immune system — specifically, how well people respond to a flu vaccine. Researchers want to understand whether opioids reduce immune system function and whether this effect is worsened in people living with HIV. **You may be eligible if...** - You have been using prescription opioids or injecting opioids for at least 90 days, OR you have never used opioids in the past year (for comparison) - If HIV-positive: you have been on HIV treatment (ART) for at least 1 year with a very low virus level in your blood - You are able to receive a flu vaccine and continue your opioid use for 4 weeks afterward **You may NOT be eligible if...** - You have a condition that would make flu vaccination unsafe - Your HIV virus is not well controlled on medication - You have had significant immune system problems unrelated to HIV or opioids Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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