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RecruitingNot ApplicableNCT04307238

Effects of Different Types of General Anesthesia on Postoperative Pupillary Reactivity

Infrared Pupillometry - Effects of Different Types of General Anesthesia on Postoperative Pupillary Reactivity

Sponsor

Medical University of Vienna

Enrollment

108 participants

Start Date

Mar 9, 2020

Study Type

INTERVENTIONAL

Conditions

Pupillary Reflex Impaired

Summary

Objective: To compare the effects of volatile and intravenous anesthetics on pupillary function after general anesthesia using a portable infrared pupillometer. Design: A monocentric, prospective, double blinded randomized study. Patients: Patients who require elective Ear, Nose and Throat (ENT) surgery under general anesthesia. Interventions: Patients undergoing elective ENT surgery will be assigned to intravenous versus inhalative anesthesia and pupillometric parameters monitored postoperative, using an infrared pupillometer. Outcomes measures: Reported pupillometric parameters after intravenous and inhalative anesthesia. The purpose of this study is to compare general anesthesia techniques (volatile, intravenous) on postoperative changes in pupillary reactivity by using infrared pupillometry.

Eligibility

Min Age: 18 YearsMax Age: 99 Years

Inclusion Criteria3

  • Patients aged ≥ 18 and ≤99 years
  • ASA I-II
  • Patients undergoing elective ENT surgery under general anesthesia

Exclusion Criteria8

  • Patients aged < 18 and >99 years
  • consumption of antidepressants, tranquilizer, psychotropic medications
  • history of mental illness, neurosurgery, neurological or psychiatric disease
  • ophthalmologic disease
  • preexisting cognitive impairment
  • Patients with drug dependence, alcoholism
  • the patients' inability to follow procedures
  • implanted electronic medical devices

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Interventions

DIAGNOSTIC_TESTPLR

PLR measurements will be performed within the first 2 postoperative hours.

DIAGNOSTIC_TESTAlertness testing

Preoperative (baseline) and every 30 minutes postoperative computer based alertness testing will be performed.

PROCEDUREPropofol anesthesia

Maintenance of anesthesia will be performed using propofol.

PROCEDURESevoflurane anesthesia

Maintenance of anesthesia will be performed using sevoflurane.

Locations(1)

Medical University Vienna

Vienna, State of Vienna, Austria

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NCT04307238