RecruitingNot ApplicableNCT04312269

Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

Sponsor

Northwestern University

Enrollment

70 participants

Start Date

Feb 25, 2020

Study Type

INTERVENTIONAL

Conditions

Stroke

Summary

This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in stroke survivors.

Eligibility

Min Age: 21 YearsMax Age: 100 Years

Inclusion Criteria4

Age at enrollment is 21 or older
Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening
Severe to moderate motor impairment (FMA-UE of 7-40)
At least some voluntary shoulder and elbow muscle activation

Exclusion Criteria9

Inability to follow instructions of the MyoCI task
Visual impairment (such as hemianopia) preventing full view of screen
Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest)
Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study
Inability to understand or follow commands in English due to aphasia or other reason
Diffuse or multifocal infarcts in both hemispheres
Substantial arm pain preventing participation for 90 minutes a day
Spasticity treatment (pharmacological or Botox) within last 3 months
Ferromagnetic implants that are MRI incompatible

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Interventions

OTHERTargeted Memory Reactivation (TMR)

Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.